Dr. Cho is a core faculty member in the Department of Basic Sciences at Bastyr University California.
Dr. Cho believes that good health care is more than medicine. His philosophy of teaching and research is to integrate the basic medical sciences with holistic health care.
Anti-Cancer Actions of Bai Tu Weng (BT), Chinese Herbal Extract
The aim of this study is analyze the genomic action of BT on tumor promoter and suppression genes in MDA-MB-231 mammary carcinoma cell line in a mid- or long-term range. Integrate genomic and non-genomic actions of anti-neoplastic BT agent on mammary carcinoma cell-line.
Gene regulation of tumor promoter and suppressor genes is involved in the most invasive MDA-MB-231 cells when BT induces cell cycle arrest by blocking signal transduction pathways at the level of MAPK as well as PI3K. Cellular mRNA during treatment with BT will be reverse-transcribed into cDNA library. First, major target genes involved in tumor suppression as well as promotion will be probed by Real Time-PCR. Second, comprehensive gene regulation by BT will be analyzed by the microarray analysis. This proposal may integrate the anti-neoplastic and cytostatic action of BT via non-genomic as well as genomic level before the follow-up in vivo (clinical) trial.