National Institute of Neurological Disorders and Stroke grant # 1R21NS070202-01A1February, 2013- January, 2015
This study explores what are the abnormalities in iron metabolism in patients with Parkinson's disease as compared to healthy controls, how diet and lifestyle factors influence iron metabolism, and how blood iron levels correlate with brain iron levels. In collaboration with Dr. Yoshimi Anzai and her team at the University of Washington, MRIs are performed to measure brain iron.
Role: Principal Investigator
Bastyr University Faculty Seed Grants #3 and #4 2009-2011, and restricted donation to Bastyr University for the Study of Neurodegenerative Diseases.Sept. 2009 - June 2012
The study focuses on the interactive effect of particular genotypes for iron-binding proteins with environmental factors such as smoking and diet, in determining changes in serum iron. This project has relevance for diseases such as Parkinson’s disease, where iron homeostasis is dysregulated. This project involves measurement of blood iron and iron-binding proteins as well as brain iron of study participants by Magnetic Resonance Imaging.
Standard Process CompanyMarch 2009 - Feb. 2010
This randomized clinical trial will evaluate the effects of 30 days of carotenoid enrichment from food, Standard Process whole-food supplement, or natural mixed carotenoid supplement on serum carotenoid concentration. This study will add to the research base regarding optimal methods of carotenoid delivery in humans as well as lend evidence supporting or refuting direct activity of carotenoids in protection of the human vasculature. It will also establish methodology for “screening” foods and natural products for endothelial protective properties.
Juvenile Diabetes Research FoundationNov. 2006 - Oct. 2008
In this project, real-time glucose monitoring was tested for its effects on parameters of oxidative stress and antioxidant status in type 1 diabetes patients, and the modifying effect of polymorphisms for oxidative-stress related genes was also studied.
Role: Research Scientist 4
National Institute of Environmental Health Sciences (NIEHS)April 2000 - March 2006
Project 5: "Environmental and Biochemical Risk Factors for Parkinson's Disease." This study investigated risks for parkinsonism related to environmental toxicants and genetic markers of susceptibility.