Survey of Cannabis Use

Cannabis has been legalized in multiple states, both medically and recreationaly, and its use becoming more widely accepted. This survey seeks to describe the use patterns, beliefs, and any therapeutic benefits or side effects experienced by Cannabis users.

Sauna Detoxification Study

The primary goal of this study is to conduct a methodologically rigorous investigation of a hyperthermia-based, medically monitored, detoxification protocol in order to assess the impact of sauna use on potential reductions in blood polychlorinated biphenyls (PCB) concentrations.

Inhibition of PP2A, but not PP5, mediates p53 activation by low levels of okadaic acid in rat liver epithelial cells

The microbial toxin okadaic acid (OA) specifically inhibits PPP-type ser/thr protein phosphatases. OA is an established tumor promoter with numerous cellular effects that include p53-mediated cell cycle arrest. In T51B rat liver epithelial cells, a model useful for tumor promotion studies, p53 activation is induced by tumor-promoting (low nanomolar) concentrations of OA. Two phosphatases sensitive to these concentrations of OA, PP2A and protein phosphatase 5 (PP5), have been implicated as negative regulators of p53.

A twin study of the effects of energy density and palatability on energy intake of individual foods.

The relative effects of energy density and palatability on energy intake, and whether there are familial influences on these effects, are not known. We investigated this issue in 7 pairs of healthy, male monozygotic twins (mean+/-SD age 26.3+/-8.6 years, BMI 23.7+/-3.2 kg/m(2)) in a clinical study involving covert ad libitum feeding of high-fat (HF, approximately 40%) and low-fat (LF, approximately 20%) diets in two 9-day phases. Diets were matched for average energy density, protein, fiber, and initial reported taste pleasantness, but these factors varied among the individual foods.

Complementary and Alternative Medical Therapies for Attention Deficit/Hyperactivity Disorder and Autism

Complementary and alternative medical (CAM) therapies are commonly used by parents for their children who have attention deficit hyperactivity disorder (ADHD) or autism spectrum disorders. The use of these therapies is well documented, yet the evidence of the safety and efficacy of these treatments in children is limited.

Acupuncture is underutilized in hospice and palliative medicine

Acupuncture is a complementary and alternative medical modality. A considerable body of acupuncture research has accumulated since 1998. Acupuncture has been integrated into palliative care settings in the United Kingdom but is yet to be widely offered in the United States. The literature was searched to identify clinical trials involving acupuncture, palliative care, hospice, chronic obstructive pulmonary disease, bone marrow, and cancer.