The Canadian/US Integrative Oncology Study (CUSIOS): Advanced Integrative Oncology Treatment for Patients with Advanced Stage Cancer: A Prospective Outcomes Study

cancer patient at home


About the Study

This observational study describes the three-year survival outcome of consecutively recruited advanced-stage breast, colorectal, ovarian, and pancreatic cancer patients receiving advanced integrative oncology (AIO) treatment at one of the participating North American advanced integrative oncology specialist clinics. This study also aims to describe AIO treatments recommended by naturopathic oncologists for these advanced-stage cancer patients and pilot the collection and evaluation of health-related quality-of-life data on a subset of Canadian AIO-treated patients.

Study Population

All stage 4 breast or colorectal cancer patients and all stage 3 or 4 ovarian and pancreatic cancer patients seeking care at the participating AIO clinical sites meeting inclusion/exclusion criteria are eligible to participate in this study.


Study Procedures

Other than a first office visit at a participating AIO clinic, there are no study visits or procedures required except for completing enrollment documents. Study data will be collected from the patient’s AIO clinic and conventional oncology records. If you’re interested in participating, contact one of the naturopathic oncologists listed below to schedule an appointment.



United States

Shelby Naturopathy PLLC (SNP), Seattle, Washington – Dr. Leanna Standish

Naturopathic Specialists, LLC (NSL), Scottsdale, Arizona – Dr. Dan Rubin

Salish Integrative Oncology Care Center (SIOCC), Fife, Washington

Hawaii Integrative Oncology, Lokahi Health Center (LHC), Kailua Kana, Hawaii – Dr. Michael Traub


Ottawa Integrative Cancer Center (OICC), Ottawa, Ontario – Dr. Dugald Seely

Vital Victoria Naturopathic Clinic Ltd. (VVNC), Victoria, British Columbia – Dr. Neil McKinney

Integrated Health Clinic Cancer Care Centre (IHCCC), Fort Langley, British Columbia – Dr. Gurdev Parmar

Marsden Centre for Excellence in Integrative Medicine, (MCEIM), Vaughan, Ontario – Dr. Eric Marsden

HealthSource Integrative Medical Centre (HSIMC(, Kitchener, Ontario – Dr. Michael Reid identifier: NCT02494037


Project Overview



Study area


Principal investigator

Leanna Standish ND, PhD, LAc, FABNO; Dugald Seely ND, MSc FABNO

Project period

January 2015 to January 2021

Completed date (for sorting)

Monday, February 1, 2021

Funded by: 

Lotte and John Hecht Foundation