Trametes versicolor-induced Immunopotentiation - Developmental Center for Research on CAM (University of Minnesota collaboration, Bastyr subcontractor)

The objectives of this developmental center grant are 1) developing basic, translational, and clinical research to explore the feasibility and scientific rationale for use of mushroom extracts as immunopotentiating agents; 2) facilitating the development of the capacity of investigators at Bastyr University to participate in basic and translational CAM research; 3) enhancing the capacity of investigators at the University of Minnesota to participate in translational and clinical CAM research.

Naturopathic Physician Research Education Project (N-PREP)

This four-year grant is funded by the National Center for Complementary and Alternative Medicine (NCCAM) at the NIH. In collaboration with colleagues at the University of Washington, Dr. Guiltinan directs the development and revision of curriculum in the naturopathic medicine program to enhance research training. Clinical exchanges and didactic programs between Bastyr University and the University of Washington provide opportunities for faculty members to further their research interests.

Echinacea for Preventing Colds in Children, Subcontract with Child Health Institute

An unexpected result of an earlier randomized controlled trial was that patients receiving Echinacea had fewer subsequent upper respiratory infections (URIs) during the four-month study period than children who received placebo for treatment of acute symptoms. This study is designed to further delineate the potential efficacy of Echinacea in preventing URIs in children.

Mechanisms of Immunomodulatory and Anti-tumor Actions of Polysaccharide Krestin

Mushroom extracts have long been used in Asia as immunopotentiating agents. Previous studies have shown that ingestion of mushroom extracts can cause tumors to shrink or stop progressing in animal models of cancer and in cancer patients. However, how these agents induce anti-tumor effects is unknown. The proposed study will use the neutransgenic (neu-tg) mouse, a model of breast cancer, to study the effects of protein-bound polysaccharide Krestin (PSK), an extract from the woody mushroom Trametes versicolor, on anti-tumor immune responses.

Preclinical studies of CAM Botanicals and Iron Overload

This study investigates effects of turmeric and its components on liver damage and liver cancer caused by iron overload. It is a laboratory based project that makes use of cell culture and mouse models of human disease.  It includes genomic and proteomic approaches to identify biomarkers of turmeric action through collaboration between investigators at Bastyr University, the Benaroya Research Institute at Virginia Mason, and the Fred Hutchinson Cancer Research Center.

Feeding the Rainbow to Investigate Endothelial Dysfunction Protocol

This project will evaluate the effects of carotenoid enrichment from food and supplements in healthy volunteers. We will also evaluate the effects of carotenoid-enrichment on biomarkers of human antioxidant capacity and acute oxidative stress-mediated endothelial dysfunction following a pro-inflammatory challenge meal.  Changes in biomarkers of chronic, oxidative cardiometabolic risk will also be evaluated.

A Comparative Effectiveness Trial of High-Quality Vitamin D3 Nutritional Supplements to Replete Serum Vitamin D

The importance of vitamin D in the prevention and treatment of diabetes and cardiovascular disease has gained increased attention in recent years. There is a need to determine what forms of vitamin D may be supplemented to correct vitamin D insufficiency and to elucidate possible mechanisms by which vitamin D sufficiency may decrease risk for developing diabetes. This randomized clinical trail will compare the effects of three different vitamin D supplements to correct insufficiency and will determine the effects of vitamin D repletion on the expression of the Klotho protein.

Intranasal Glutathione in Parkinson's Disease

Parkinson's disease (PD) is considered a progressive and irreversible neurodegenerative disease. Current therapies improve disease symptoms, however none alter the underlying degenerative course. Research suggests the loss of brain glutathione, a powerful antioxidant, is one of the earliest changes to occur in the brain of PD patients and the magnitude of glutathione depletion parallels the severity of PD. This study will look at the use of intranasal glutathione in PD patients to determine safety, tolerability, and the impact on PD symptoms.